CYTOGENETIC STUDIES IN 5 PATIENTS WITH SEZARY-SYNDROME

Authors
SOLE F WOESSNER S VALLESPI T LOSADA AP FLORENSA L IRRIGUIBLE D VILA J SANSSABRAFEN J
Citation
F. Sole et al., CYTOGENETIC STUDIES IN 5 PATIENTS WITH SEZARY-SYNDROME, Cancer genetics and cytogenetics, 75(2), 1994, pp. 130-132
Citations number
19
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
75
Issue
2
Year of publication
1994
Pages
130 - 132
Database
ISI
SICI code
0165-4608(1994)75:2<130:CSI5PW>2.0.ZU;2-B
Abstract
A cytogenetic study was performed in five patients with Sezary syndrom e. Metaphases were obtained from a phytohemaggluyinin-stimulated lymph ocyte culture. The five patients showed abnormal karyotypes. The chrom osomes preferentially involved in numerical aberrations were chromosom es 10 (monosomy) and 13 (monosomy); involved in structural changes wer e chromosomes 1, 2, 4, 6, and 14. In our series, all patients showed p rogression of the disease.