We have undertaken cytogenetic investigation of seven benign and malig
nant lacrimal gland neoplasms. This study showed recurrent chromosomal
abnormalities involving chromosomes 3, 8, 9, and 12. These features a
re similar to those found in benign and malignant salivary gland tumor
s, which suggests possible common mechanisms involved in the neoplasti
c proliferation of these histologically related tumors.