Am. Deakin et al., ROLE OF POTASSIUM CHANNELS IN THE REGULATION OF CYTOKINE RELEASE FROMTHP-1 CELLS, Agents and actions, 41, 1994, pp. 30000188-30000190
The role of K+ channels in the regulation of cytokine release was inve
stigated. Quinine, a non-selective K+ channel blocking agent inhibited
both TNF alpha and IL-1 beta release but had non-specific effects on
cell. function. Glipizide and glibenclamide, inhibitors of ATP-sensiti
ve K+ channels, reduced IL-1 beta release but not TNF alpha, whereas a
pamin, a selective inhibitor of low-conductance Ca2+- sensitive channe
ls, inhibited TNF alpha. release, potentiated IL-1 beta but had no eff
ect on IL-6 or IL-8 release. These results suggest that K+ channels ma
y differentially regulate cytokine production by THP-1 cells.