MATRIX METALLOPROTEASE INHIBITORY EFFECT OF ENDOTHELIAL-CELL CONTACT DURING EXOCYTOSIS OF ADHERENT NEUTROPHILS

Authors
ZAOUI P BOULAY F BARRO C GUILLOT M BERTHIER S MOREL F
Citation
P. Zaoui et al., MATRIX METALLOPROTEASE INHIBITORY EFFECT OF ENDOTHELIAL-CELL CONTACT DURING EXOCYTOSIS OF ADHERENT NEUTROPHILS, Agents and actions, 41, 1994, pp. 30000195-30000197
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
41
Year of publication
1994
Pages
30000195 - 30000197
Database
ISI
SICI code
0065-4299(1994)41:<30000195:MMIEOE>2.0.ZU;2-7
Abstract
Basal membrane turnover implies the regulation of specific metalloprot eases (MMP) with cleavage abilities for collagen IV. We have set up a model of neutrophil (PMN)-endothelial interaction in vitro which allow ed to observe a net gelatinase exocytosis when PMN. adhered to plastic substrates. When PMN adhered to endothelial monolayers, this activity was significantly diminished (-30%; p<0.05) and furthermore, RNA tran scripts for MMP were specifically down-regulated. Our study points to an endothelial inhibitory regulation of matrix remodeling during PMN-e ndothelial interaction.