Ma. Trevethick et al., NEUTROPHIL DEPLETION DOES NOT PREVENT INDOMETHACIN-INDUCED ULCERATIONOF THE RAT GASTRIC ANTRUM, Agents and actions, 41, 1994, pp. 30000226-30000227
Indomethacin-induced ulceration of the rat gastric antrum is parallele
d by an increase in blood neutrophil numbers and of neutrophil infiltr
ation into the antrum. Thus, in this study, neutrophil depletion has b
een employed to study the potential role of neutrophils in the pathoge
nesis of indomethacin-induced ulceration of the rat gastric antrum. Pr
etreatment with an anti-neutrophil serum (ANS) induced a near complete
neutropaenia and inhibition of neutrophil infiltration into the gastr
ic antrum (as assessed by antral LTB(4) release). In contrast, ANS pre
treatment did not alter the area of indomethacin-induced mucosal damag
e detected microscopically. Our results suggest that, in contrast to p
ublished reports examining fundic ulceration, neutrophil infiltration
does not contribute to the ulcerogenic effects of indomethacin in the
rat gastric antrum.