AMPLIFICATION OF A C-YES-1-RELATED ONCOGENE IN CANINE LYMPHOID LEUKEMIA

Genomic DNAs from 4 canine spontaneous lymphoid neoplasms were examine d by Southern blot hybridization using 7 kinds of oncogene probes. Ana lysis using a human c-yes-1 cDNA probe revealed amplification of the p roto-oncogene in a DNA sample from a dog with lymphoid leukemia. Its d egree was about 4- to 8- fold in comparison with a control DNA sample from a healthy dog. The genomic abnormality of canine c-yes-1-related oncogene may have a role in the tumorigenesis of this neoplasm, althou gh the significance of the structural change in this oncogene remains unclear.