MECHANISM OF ENDOGENOUS VASOMOTILITY AND SMOOTH-MUSCLE INSUFFICIENCY IN THE MICROCIRCULATORY BED

The paper outlines the previously unknown smooth muscle insufficiency in terms of its etiology, pathogenesis, diagnosis and treatment. It ha s been shown that drug administration leads to smooth muscle insuffici ency which is eliminated by serotonin both in vitro and in vivo. The c linical manifestations of smooth muscle (SM) insufficiency are elimina ted by serotonin, irrespective of whether it has been caused by the us e of drugs or impaired smooth muscle innervation. The mechanism of vas cular rhythmic oscillations in the microcirculatory bed, the so-called endogenous vasomotility (EV) has been decoded. The mechanism of EV re gulation is due to the fact that platelets constantly (continuously) a dsorb serotonin from the enterochromaffin cells of the gastrointestina l tract and constantly (continuously) release it into the microcircula tory bed, thereby providing the continuum of entry of the stimulant to the SM fibers which are able to contract at this time. The summation of these contractions of smooth muscle contractions in the microcircul atory bed maintains their vascular tone and yields the pattern of EV. The paper also describes the earlier unknown properties of hemoglobin and myoglobin to cause smooth muscle spasm and to accelerate platelet destruction. A correlation between the EV and vascular platelet hemost asis is described in terms of these properties. The continuous mechani sm of EV is impaired and it transforms to intermittent (final) vascula r platelet hemostasis.