POSSIBLE USE OF DALARGIN IN THE INTENSIVE -CARE OF EMERGENCIES

The paper analyzes whether the national synthethic leuenkephalin analo gue dalargin can be used in the prevention and treatment of postoperat ive polyorgan deficiency. Dalargin has been experimentally demonstrate d to be effective in preventing impairments in transcapillary fluid ex change, by stopping the development of pulmonary edema. The use of the drug in the intra- and postoperative perid in patients undergone card iac surgery during general assisted circulation reduced the incidence substantially and decreased the severity of respiratory distress syndr ome. The experimental and clinical findings suggest that dalargin has pulmono-, hepato-, and pancreatoprotective properties. Thus, dalargin should be used in the multimodality intensive care of postoperative po lyorgan deficiency.