SYNTENIC ASSIGNMENT OF HUMAN-CHROMOSOME-1 HOMOLOGOUS LOCI IN THE BOVINE

Three mouse chromosomes (MMU 1, 3, and 4) carry homologs of human chro mosome 1 (HSA 1) genes. A similar situation is found in the bovine, wh ere five bovine chromosomes (BTA 2, 3, 5, 16, and unassigned syntenic group U25) contain homologs of HSA 1 loci. To evaluate further the syn tenic relationship of HSA 1 homologs in cattle, 10 loci have been phys ically mapped through segregation analysis in bovine-rodent hybrid som atic cells. These loci, chosen for their location on HSA 1, are antith rombin 3 (AT3), renin (REN), complement component receptor 2 (CR2), ph osphofructokinase muscle type (PFKM), Gardner-Rasheed feline sarcoma v iral (upsilon-fgr) oncogene homolog (FGR), alpha fucosidase (FUCA1), G -protein beta 1 subunit (GNB1), alpha 1A amylase, (AMY1), the neurobla stoma RAS viral (upsilon-ras) oncogene homolog (NRAS), and alpha skele tal actin (ACTA1). AT3, REN, CR2, and GNB1 mapped to BTA 16, PFKM to B TA 5, AMY1A and NRAS to BTA 3, FGR and FUCA1 to BTA 2, and ACTA1 to BT A 28. (C) 1994 Academic Press, Inc.