THE MOUSE AND HUMAN EXCITATORY AMINO-ACID TRANSPORTER GENE (EAAT1) MAPS TO MOUSE CHROMOSOME-15 AND A REGION OF SYNTENIC HOMOLOGY ON HUMAN-CHROMOSOME-5

The gene for human excitatory amino acid transporter (EAAT1) was local ized to the distal region of human chromosome 5p13 by in situ hybridiz ation of metaphase chromosome spreads. Interspecific backcross analysi s identified the mouse Eaat1 locus in a region of 5p13 homology on mou se chromosome 15. Markers that are linked with EAAT1 on both human and mouse chromosomes include the receptors for leukemia inhibitory facto r, interleukin-7, and prolactin. The Eaat1 locus appears not to be lin ked to the epilepsy mutant stg locus, which is also on chromosome 15. The EAAT1 locus is located in a region of 5p deletions that have been associated with mental retardation and microcephaly. (C) 1994 Academic Press, Inc.