ADAPTATION TO MULTIPLE ELECTROSTIMULATION LIMITS HEMORRHAGES IN THE BRAIN OF RATS WITH AUDIOGENIC EPILEPSY

Exposure of Krushinsky-Molodkina rats (a strain genetically predispose d to audiogenic epilepsy) to multiple electrostimulation (a course con sisting of 10 sessions) prolongs the latency of epileptic seizures, lo wers blood levels of stress hormones, lessens the severity of seizures , and reduces by half the area occupied by subdural hemorrhages. It is concluded that the major role in the mechanism of these protective ef fects is played by adaptation to stress, accompanied by the accumulati on in the brain of heat-shock proteins that stabilize cellular structu res.