An interrelationship between primary and secondary metabolites of a to
xigenic mould (Aspergillus parasiticus var. globosus IMI 120920) was o
btained in liquid broth containing various concentrations of dithane Z
-78 and propoxur. The results show that a stimulatory response was rec
orded in gibberellin, protein. sterol and aflatoxin yield in cultures
treated with 15, 30, 50 and 100 ppm a.i. of dithane Z-78. On the other
hand, propoxur reduced the yield of gibberellin, amino acids, protein
, sterol and aflatoxin. In comparison to its effect on the mycelial gr
owth, gibberellin and anatoxin activity is inhibited more severly than
dry weight increase, thus leading to the assumption that there is a s
pecific effect of the inhibitor on both gibberellin and aflatoxin synt
hesis.