INHIBITORY EFFECT OF PERINDOPRIL, A NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR, ON NEOINTIMA FORMATION AFTER BALLOON INJURY IN RATS AND CHOLESTEROL-FED RABBITS

Citation
T. Shibutani et al., INHIBITORY EFFECT OF PERINDOPRIL, A NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR, ON NEOINTIMA FORMATION AFTER BALLOON INJURY IN RATS AND CHOLESTEROL-FED RABBITS, Journal of cardiovascular pharmacology, 24(3), 1994, pp. 509-516
Citations number
47
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System","Pharmacology & Pharmacy
ISSN journal
01602446
Volume
24
Issue
3
Year of publication
1994
Pages
509 - 516
Database
ISI
SICI code
0160-2446(1994)24:3<509:IEOPAN>2.0.ZU;2-A
Abstract
We investigated the effect of perindopril, a novel angiotensin-convert ing enzyme (ACE) inhibitor, on neointima formation in vessel walls aft er balloon injury in rats (carotid artery) and cholesterol-fed rabbits (thoracic aorta). Continuous treatment with perindopril significantly reduced neointima formation in both species, as compared with the con trol group: intima/media (I/M) ratio (rats -62% p < 0.001; rabbits -25 %, p < 0.05); neointima area (rats -65%, p < 0.01; rabbits -24%, p < 0 .05). These changes involved reduction of intimal smooth muscle cells (SMC) in rats and of macrophages in rabbits. Furthermore, perindopril also significantly decreased ACE activity in both aortic tissue and se rum [11.38 +/- 0.87 vs. 34.93 +/- 6.44 pmol His-Leu (HL)/mg/min (p < 0 .01) and 2.79 +/- 0.28 vs. 38.50 +/- 5.41 pmol HL/mg min (p < 0.001), respectively], aortic contraction evoked by angiotensin I (AI) and mea n blood pressure (BP, 84.9 +/- 3.5 vs. 109.3 +/- 3.8 mm Hg, p < 0.001) as compared with control values. These results indicate that perindop ril may reduce neointima formation by suppressing the aortic renin-ang iotensin system (RAS). These findings indicate that perindopril may be capable of preventing testenotic lesions after angioplasty in humans.