INHIBITORY EFFECT OF PERINDOPRIL, A NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR, ON NEOINTIMA FORMATION AFTER BALLOON INJURY IN RATS AND CHOLESTEROL-FED RABBITS
T. Shibutani et al., INHIBITORY EFFECT OF PERINDOPRIL, A NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR, ON NEOINTIMA FORMATION AFTER BALLOON INJURY IN RATS AND CHOLESTEROL-FED RABBITS, Journal of cardiovascular pharmacology, 24(3), 1994, pp. 509-516
We investigated the effect of perindopril, a novel angiotensin-convert
ing enzyme (ACE) inhibitor, on neointima formation in vessel walls aft
er balloon injury in rats (carotid artery) and cholesterol-fed rabbits
(thoracic aorta). Continuous treatment with perindopril significantly
reduced neointima formation in both species, as compared with the con
trol group: intima/media (I/M) ratio (rats -62% p < 0.001; rabbits -25
%, p < 0.05); neointima area (rats -65%, p < 0.01; rabbits -24%, p < 0
.05). These changes involved reduction of intimal smooth muscle cells
(SMC) in rats and of macrophages in rabbits. Furthermore, perindopril
also significantly decreased ACE activity in both aortic tissue and se
rum [11.38 +/- 0.87 vs. 34.93 +/- 6.44 pmol His-Leu (HL)/mg/min (p < 0
.01) and 2.79 +/- 0.28 vs. 38.50 +/- 5.41 pmol HL/mg min (p < 0.001),
respectively], aortic contraction evoked by angiotensin I (AI) and mea
n blood pressure (BP, 84.9 +/- 3.5 vs. 109.3 +/- 3.8 mm Hg, p < 0.001)
as compared with control values. These results indicate that perindop
ril may reduce neointima formation by suppressing the aortic renin-ang
iotensin system (RAS). These findings indicate that perindopril may be
capable of preventing testenotic lesions after angioplasty in humans.