J. Fujita et al., ERYTHROCYTE SODIUM-LITHIUM COUNTERTRANSPORT ACTIVITY AS A MARKER OF PREDISPOSITION TO HYPERTENSION AND DIABETIC NEPHROPATHY IN NIDDM, Diabetes care, 17(9), 1994, pp. 977-982
Citations number
27
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
OBJECTIVE- To evaluate the potentiality of erythrocyte sodium-lithium
countertransport activity (SLC) as a marker of predisposition to hyper
tension and diabetic nephropathy in non-insulin-dependent diabetes mel
litus (NIDDM). RESEARCH DESIGN AND METHODS- We examined 96 patients wi
th NIDDM and 26 healthy control subjects. SLC and other data were comp
ared among subgroups of the patients classified on the basis of hypert
ension, family history of hypertension, and stages of nephropathy. Dat
a were also analyzed by stepwise multiple regression analyses. RESULTS
- SLC was significantly higher in patients with hypertension than in t
hose with normotension and significantly higher in patients with a pos
itive family history of hypertension than in the negative group. Furth
er analysis revealed that a family history of hypertension has indepen
dent influence on SLC, but hypertension itself does not. SLC was signi
ficantly higher in patients with macroalbuminuria than with microalbum
inuria and;higher in patients with microalbuminuria than with normoalb
uminuria. In stepwise multiple regression analyses, a family history o
f hypertension was the most important determinant of SLC, and SLC was
the most important determinant of nephropathy. CONCLUSIONS- These data
suggest that SLC strongly reflects a predisposition to hypertension a
nd that it can be a useful marker of diabetic nephropathy in NIDDM.