AN EFFICIENT SYNTHESIS OF 2-CHLORO-3-CARBOETHOXY OR 2-CHLORO-3-CYANO 4,5-DISUBSTITUTED AND 5-SUBSTITUTED PYRROLES

Authors
FOLEY LH
Citation
Lh. Foley, AN EFFICIENT SYNTHESIS OF 2-CHLORO-3-CARBOETHOXY OR 2-CHLORO-3-CYANO 4,5-DISUBSTITUTED AND 5-SUBSTITUTED PYRROLES, Tetrahedron letters, 35(33), 1994, pp. 5989-5992
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
33
Year of publication
1994
Pages
5989 - 5992
Database
ISI
SICI code
0040-4039(1994)35:33<5989:AESO2O>2.0.ZU;2-4
Abstract
Reaction of substituted 2-cyano-4-oxo-alkanoic acid ethyl esters or 2- cyano-4-oxo-alkanonitriles with HCl gas in 2-propanol or concentrated HCl in 2-propanol for the dinitriles provides an efficient synthesis o f substituted 2-chloropyrroles from readily available starting materia ls and reagents.