FLUOROOLEFIN PEPTIDE ISOSTERES - TOOLS FOR CONTROLLING PEPTIDE CONFORMATIONS

Authors
BOROS LG DECORTE B GIMI RH WELCH JT WU Y HANDSCHUMACHER RE
Citation
Lg. Boros et al., FLUOROOLEFIN PEPTIDE ISOSTERES - TOOLS FOR CONTROLLING PEPTIDE CONFORMATIONS, Tetrahedron letters, 35(33), 1994, pp. 6033-6036
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
33
Year of publication
1994
Pages
6033 - 6036
Database
ISI
SICI code
0040-4039(1994)35:33<6033:FPI-TF>2.0.ZU;2-4
Abstract
Fluoroolefin dipeptide isosteres were synthesized applying the Peterso n reaction as a novel for fluoroolefination. The dipeptide isosteres w ere elaborated to provide the conformationally constrained analogs (1- (R), 1-(S) and 2-(R), 2-(S)) of the Suc-Ala-Gly-Pro-Phe-pNA tetrapepti de, a synthetic substrate of cyclophilin.