EXTRACARDIAC ANOMALIES, ANEUPLOIDY AND GROWTH-RETARDATION IN 100 CONSECUTIVE FETAL CONGENITAL HEART-DEFECTS

The importance of extracardiac anomalies in 100 consecutive fetuses wi th congenital heart disease was evaluated The most common cardiac diag noses were hypoplastic left heart syndrome in 35% and atrioventricular canal defect in 15%. Extracardiac anomalies were present in 42%, abno rmal karyotype in 19% and intrauterine growth retardation in 20%. Ther e were 45 survivors (35 required neonatal surgery, ten did not require early surgery) and 80% (36/45) of the survivors had isolated congenit al heart disease. Extracardiac anomalies and abnormal karyotype were m ore frequently present in non-survivors (p < 0.001). Also, intrauterin e growth retardation was more frequent in non-survivors (p < 0.05).