CHRONIC ETHANOL EFFECTS ON GLYCOCONJUGATES AND GLYCOSYLTRANSFERASES OF RAT-BRAIN

Citation
F. Omodeosale et P. Palestini, CHRONIC ETHANOL EFFECTS ON GLYCOCONJUGATES AND GLYCOSYLTRANSFERASES OF RAT-BRAIN, Alcohol, 11(4), 1994, pp. 301-306
Citations number
47
Categorie Soggetti
Substance Abuse","Pharmacology & Pharmacy",Toxicology
Journal title
ISSN journal
07418329
Volume
11
Issue
4
Year of publication
1994
Pages
301 - 306
Database
ISI
SICI code
0741-8329(1994)11:4<301:CEEOGA>2.0.ZU;2-7
Abstract
We studied the effects of a four week administration of low doses of e thanol on glycoconjugates of the synaptosomal and microsomal fraction prepared from the brain of rats aged 2 and 7 months. Synaptosomes were the more sensitive to ethanol treatment. Total lipid bound sialic aci d and neutral glycolipid and glycoprotein content were significantly r educed only in the synaptosomal fraction, with greater differences in the younger age, while glycoprotein sialic acid was not affected. None of the above differences were statistically significant in the micros omal fraction. Ganglioside pattern was altered only in the 2 month rat s, showing a reduction of GM1 and GD1a in the synaptosomal fraction an d of GD1a in the microsomal fraction. UDP-Gal:asialo-mucin galactosylt ransferase, UDP-Gal:GlcCer galactosyltransferase, and UDP-Gal:GM2 gala ctosyltransferase activities were decreased and could account for the observed modifications in glycoconjugate content and distribution.