ANGIOTENSIN AT(1) RECEPTOR BLOCKADE BY SPECIFIC ANTIBODY PREVENTED 2-KIDNEY, ONE-CLIP RENAL-HYPERTENSION IN THE RAT

Authors
ZELEZNA B VESELSKY L VELEK J ZICHA J KUNES J
Citation
B. Zelezna et al., ANGIOTENSIN AT(1) RECEPTOR BLOCKADE BY SPECIFIC ANTIBODY PREVENTED 2-KIDNEY, ONE-CLIP RENAL-HYPERTENSION IN THE RAT, European journal of pharmacology, 260(1), 1994, pp. 95-98
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
260
Issue
1
Year of publication
1994
Pages
95 - 98
Database
ISI
SICI code
0014-2999(1994)260:1<95:AARBBS>2.0.ZU;2-2
Abstract
The effect of chronic angiotensin AT(1) receptor blockade by a specifi c antibody on the development of two-kidney, one-clip renal hypertensi on was studied in Wistar rats. Renal artery constriction resulted in a fast and large increase in blood pressure in comparison with that of control rats. On the other hand, the pre-immunization of rats with a s mall part of the angiotensin AT(1) receptor completely prevented the d evelopment of renal hypertension. We conclude that the development of two-kidney, one-clip renal hypertension can be blocked by a specific a ntibody raised against a part of the angiotensin AT(1) receptor.