NITRIC-OXIDE AS MEDIATOR OF THE GASTROPROTECTION BY CHOLECYSTOKININ-8AND PENTAGASTRIN

Authors
STROFF T LAMBRECHT N PESKAR BM
Citation
T. Stroff et al., NITRIC-OXIDE AS MEDIATOR OF THE GASTROPROTECTION BY CHOLECYSTOKININ-8AND PENTAGASTRIN, European journal of pharmacology, 260(1), 1994, pp. 180000001-180000002
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
260
Issue
1
Year of publication
1994
Pages
180000001 - 180000002
Database
ISI
SICI code
0014-2999(1994)260:1<180000001:NAMOTG>2.0.ZU;2-E
Abstract
Cholecystokinin-8 and pentagastrin protect against ethanol-induced gas tric mucosal lesions in rats. The protective effect is antagonized by the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine, The in hibitory action of N-G-nitro-L-arginine is reversed by L-arginine, but not D-arginine. The findings suggest that NO is involved in the gastr oprotection induced by both peptides.