Objectives: To review the complications and contraindications associat
ed with cutaneous cryotherapy, and to describe the prevention of compl
ications by appropriate technique, with consideration of the type of l
esion being treated, the anatomical site and recognition of the high-r
isk patient. Data sources and selection: We reviewed published work (i
n English) from 1982 to 1993. All commonly cited complications are pre
sented and described. Conclusions: Cutaneous cryotherapy generally has
few complications. However, serious adverse events have been reported
, and should be noted by all clinicians using cryotherapy. With adequa
te training, appropriate patient selection and the use of suitable cry
otherapy regimens, cutaneous cryotherapy provides safe and effective t
reatment for a wide variety of cutaneous lesions.