ANTIBODY-RESPONSE TO ADENOVIRUS E1B-DERIVED SYNTHETIC PEPTIDES AND SERUM LEVELS OF P53 IN PATIENTS WITH GASTROINTESTINAL AND OTHER MALIGNANT-LYMPHOMAS

Serum levels of p53 and antipeptide antibody levels to adenovirus type 12 (Ad12) E1b protein were measured in a case-control study of 62 new ly diagnosed patients with malignant lymphoma. While patients with gas trointestinal lymphoma did not differ from their matched controls, p53 positive lymphoma patients had significantly (P < 0.04) increased ant ipeptide IgG antibody levels to the Ad12 E1b. Concomitant detection of serum p53 and antipeptide antibodies to Ad12 E1b was associated with an increased risk (OR = 17.0, 95% confidence limits 1.5, 58.5) of mali gnant lymphoma suggesting synergism between expression of Ad 12 E1b an d accumulation of p53 in patients with malignant lymphoma. (C) 1994 Wi ley-Liss, Inc.