Ml. Lahdeaho et al., ANTIBODY-RESPONSE TO ADENOVIRUS E1B-DERIVED SYNTHETIC PEPTIDES AND SERUM LEVELS OF P53 IN PATIENTS WITH GASTROINTESTINAL AND OTHER MALIGNANT-LYMPHOMAS, Journal of medical virology, 43(4), 1994, pp. 393-396
Serum levels of p53 and antipeptide antibody levels to adenovirus type
12 (Ad12) E1b protein were measured in a case-control study of 62 new
ly diagnosed patients with malignant lymphoma. While patients with gas
trointestinal lymphoma did not differ from their matched controls, p53
positive lymphoma patients had significantly (P < 0.04) increased ant
ipeptide IgG antibody levels to the Ad12 E1b. Concomitant detection of
serum p53 and antipeptide antibodies to Ad12 E1b was associated with
an increased risk (OR = 17.0, 95% confidence limits 1.5, 58.5) of mali
gnant lymphoma suggesting synergism between expression of Ad 12 E1b an
d accumulation of p53 in patients with malignant lymphoma. (C) 1994 Wi
ley-Liss, Inc.