A CHEMOSELECTIVE APPROACH TO FUNCTIONALIZE THE C-10 POSITION OF 10-DEACETYLBACCATIN .3. SYNTHESIS AND BIOLOGICAL PROPERTIES OF NOVEL C-10 TAXOL(R) ANALOGS

A chemoselective approach to functionalize the C-10 position of 10-dea cetyl baccatin III, a key intermediate for the semi-synthesis of pacli taxel, is described. The chemistry provides an easy access to a variet y of C-10 hydroxyl derivatives, such as, ethers, esters, carbonates, c arbamates, and sulfonates under mild conditions. The C-10 modified bac catin derivatives were further employed in the synthesis of never biol ogically active Taxol(R) analogues.