CONTINUOUS COMBINED AND SEQUENTIAL ESTRADIOL AND NORETHINDRONE ACETATE TREATMENT OF POSTMENOPAUSAL WOMEN - EFFECT ON PLASMA-LIPOPROTEINS INA 2-YEAR PLACEBO-CONTROLLED TRIAL

Citation
N. Munkjensen et al., CONTINUOUS COMBINED AND SEQUENTIAL ESTRADIOL AND NORETHINDRONE ACETATE TREATMENT OF POSTMENOPAUSAL WOMEN - EFFECT ON PLASMA-LIPOPROTEINS INA 2-YEAR PLACEBO-CONTROLLED TRIAL, American journal of obstetrics and gynecology, 171(1), 1994, pp. 132-138
Citations number
25
Categorie Soggetti
Obsetric & Gynecology
ISSN journal
00029378
Volume
171
Issue
1
Year of publication
1994
Pages
132 - 138
Database
ISI
SICI code
0002-9378(1994)171:1<132:CCASEA>2.0.ZU;2-A
Abstract
OBJECTIVE: Our purpose was to examine the effects of postmenopausal es trogen therapy supplemented with progestogen on plasma lipoprotein lev els. STUDY DESIGN: One hundred thirteen women were randomized to recei ve either placebo or a combination of 17 beta-estradiol and norethindr one acetate administered continuously (Kliogest) or sequentially (Tris equens). Plasma lipoprotein levels were measured at baseline and after 2 years of treatment and compared by analysis of variance. RESULTS: H ormone therapy lowered plasma cholesterol levels (p < 0.001) and low-d ensity lipoprotein cholesterol (Kliogest, p < 0.001; Trisequens, p < 0 .01), whereas high-density lipoprotein cholesterol levels were unchang ed (Trisequens) or reduced (Kliogest, p < 0.01), primarily because of a decrease in the high-density lipoprotein-2 subfraction (p < 0.05). L ow-density lipoprotein/high-density lipoprotein cholesterol ratios rem ained unchanged. CONCLUSIONS: Although hormonal replacement therapy wi th estradiol combined with norethindrone acetate eliminated the increa se in high-density lipoprotein cholesterol levels observed with estrog en monotherapy, the reductions in low-density lipoprotein cholesterol concentrations still suggest reduced cardiovascular risk, according to the National Cholesterol Education Program and to recent observations indicating that risk is not necessarily inversely proportional to hig h-density lipoprotein cholesterol levels.