Citation
M. Berkovitch et al., PEDIATRIC CLINICAL USE OF THE KETOCONAZOLE CYCLOSPORINE INTERACTION, Pediatric nephrology, 8(4), 1994, pp. 492-493
Citations number
NO
Categorie Soggetti
Pediatrics,"Urology & Nephrology
Journal title
Pediatric nephrology
ISSN journal
0931041X
→ ACNP
Volume
8
Issue
4
Year of publication
1994
Pages
492 - 493
Database
ISI
SICI code
0931-041X(1994)8:4<492:PCUOTK>2.0.ZU;2-3
Abstract
Ketoconazole is known to inhibit the metabolism of cyclosporin through
inhibition of cytochrome P-450. This pharmacological interaction was
used in an 8-year-old renal transplant patient to successfully achieve
therapeutic cyclosporin blood concentrations. The addition of ketocon
azole to the cyclosporin regimen should be considered when difficultie
s are encountered in attaining satisfactory cyclosporin levels.