H. Yoshida et al., BILE-FLOW IN A MUTANT SPRAGUE-DAWLEY RAT WITH DEFECTIVE BILIARY-EXCRETION OF GLUTATHIONE, Journal of gastroenterology, 29(4), 1994, pp. 439-442
The Eisai hyperbilirubinemic rat is a mutant strain of Sprague-Dawley
origin with hereditary defects in the biliary excretion of bilirubin g
lucuronide, glutathione, and several other organic anions. The correla
tion between bile flow and bile acid excretion rates during taurochola
te infusion revealed that bile acid-independent flow was smaller in th
e mutant than in intact Sprague-Dawley rats (19.3 vs 56.0 mul/kg per m
in), while bile acid-dependent flow was similar. The correlation betwe
en bile flow and glutathione excretion rates in Sprague-Dawley rats wi
th modified hepatic glutathione levels revealed that a certain portion
of bile flow was proportional to the biliary excretion of glutathione
, with a coefficient of 551 bile per 1 mol glutathione. One-third of b
ile acid-independent bile flow in intact Sprague-Dawley rats was accou
nted for by glutathione osmosis, which feature was absent in the mutan
t rats.