THE SYNTHESIS OF A WATER-SOLUBLE COMPLEMENT ACTIVATING POLYACRYLIC-ACID IGG POLYMER

Authors
SCHMER G HENDERSON RA MULLER W
Citation
G. Schmer et al., THE SYNTHESIS OF A WATER-SOLUBLE COMPLEMENT ACTIVATING POLYACRYLIC-ACID IGG POLYMER, Journal of biomaterials science. Polymer ed., 6(1), 1994, pp. 67-78
Citations number
18
Categorie Soggetti
Engineering, Biomedical","Polymer Sciences","Materials Science, Biomaterials
Journal title
Journal of biomaterials science. Polymer ed. → ACNP
ISSN journal
09205063
Volume
6
Issue
1
Year of publication
1994
Pages
67 - 78
Database
ISI
SICI code
0920-5063(1994)6:1<67:TSOAWC>2.0.ZU;2-#
Abstract
Polyacrylic acid-IgG polymer (PAA-IgG) activates the classical and alt ernative pathway of complement as shown by specific C1q-(IgG-PAA) inte raction and the generation of C4d, Bb, C3b, C3a and C5a. This water so luble and stable PAA-IgG polymer represents a model substance for the study of humoral and cellular inflammatory mechanisms, mediated by the complement system.