PHARMACOKINETIC RESULTS ON NAPROXEN PRODRUGS BASED ON POLY(ETHYLENEGLYCOL)S

Authors
RANUCCI E SARTORE L PERONI I LATINI R BERNASCONI R FERRUTI P
Citation
E. Ranucci et al., PHARMACOKINETIC RESULTS ON NAPROXEN PRODRUGS BASED ON POLY(ETHYLENEGLYCOL)S, Journal of biomaterials science. Polymer ed., 6(2), 1994, pp. 141-147
Citations number
8
Categorie Soggetti
Engineering, Biomedical","Polymer Sciences","Materials Science, Biomaterials
Journal title
Journal of biomaterials science. Polymer ed. → ACNP
ISSN journal
09205063
Volume
6
Issue
2
Year of publication
1994
Pages
141 - 147
Database
ISI
SICI code
0920-5063(1994)6:2<141:PRONPB>2.0.ZU;2-6
Abstract
Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen ), in which the drug was bound by ester linkages to diethyleneglycol ( I), triethyleneglycol (II), octanediol (III), butyl triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared a nd tested for their pharmacokinetic properties after oral administrati on. It was found that bioavailabilities decreased in the order, and in all cases were lower than that of the free drug.