THE CONCENTRATION OF SPARFLOXACIN IN LUNG TISSUES AFTER SINGLE AND MULTIPLE ORAL DOSES

The levels of sparfloxacin were measured in serum, alveolar macrophage s, epithelial lining fluid (ELF) and bronchial mucosa after single and multiple oral doses. Measurement was performed using a microbiologica l assay technique. There were 21 subjects in the single dose and 10 su bjects in the multiple dose groups. Following a single 400 mg dose of sparfloxacin the mean levels after 11-15 h were 1.2 mg/l in serum, 61. 3 mg/l in macrophages, 9.8 mg/l in ELF and 2.6 mg/kg in mucosa. After multiple dosing of 400 mg on day 1 followed by 200 mg daily for the ne xt 2 days the mean levels were 1.2 mg/l in serum, 53.7 mg/l in macroph ages, 15.0 mg/l in ELF and 4.4 mg/kg in mucosa. These data predict goo d clinical efficacy in respiratory tract infections.