We investigated the possible effects of acetic acid bacterium on ethan
ol oxidation in vivo by monitoring the blood ethanol level after injec
ting 5% ethanol with (treated group) or without (control group) a free
ze-dried bacterial cell suspension directly into the stomach of anesth
esized rats. Paired comparison t-tests of the results indicate that th
e blood ethanol concentration of the rats in the treated group was sig
nificantly (p < 0.07) lower than that in the control group. When measu
red 10 min after administering ethanol into the gullet, the concentrat
ion in the stomach of the rats that received acetic acid bacterium sim
ultaneously with ethanol was significantly (p < 0.10) lower than that
of the rats that received ethanol alone. We consider that freeze-dried
cells of acetic acid bacterium oxidized ethanol in the stomach and co
uld be effective for reducing the blood ethanol level after drinking.