THE T-GENES IN EMBRYOGENESIS

Authors
HERRMANN BG KISPERT A
Citation
Bg. Herrmann et A. Kispert, THE T-GENES IN EMBRYOGENESIS, Trends in genetics, 10(8), 1994, pp. 280-286
Citations number
33
Categorie Soggetti
Genetics & Heredity
Journal title
Trends in genetics → ACNP
ISSN journal
01689525
Volume
10
Issue
8
Year of publication
1994
Pages
280 - 286
Database
ISI
SICI code
0168-9525(1994)10:8<280:TTIE>2.0.ZU;2-N
Abstract
Since its identification in 1927, the mouse T (Brachyury) locus has be en implicated in mesoderm formation and and notochord differentiation Recent work; has demonstrated that this gene encodes a putative transc ription factor expressed specifically in nascent mesoderm and in the d ifferentiating notochord. Homologous genes have been cloned from the f rog Xenopus laevis, the zebrafish Brachydanio rerio and the ascidian H alocynthia roretzi. The T gene is an important tool for elucidating me sodermal and embryonic pattern formation.