CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF A TRIMERIC FORM OF HUMAN MANNOSE-BINDING PROTEIN

A trimeric form of the carbohydrate recognition domain of human mannos e binding protein has been crystallized in two different forms. The fi rst form crystallizes with symmetry consistent with space group P2(1)2 (1)2(1) and a = 61 Angstrom; b = 144 Angstrom; c = 107 Angstrom with p resumably two trimers in the asymmetric unit. The second form crystall izes with symmetry consistent with space group P321 and a = b = 77 Ang strom; c = 58 Angstrom and one monomer per asymmetric unit. The molecu lar and crystallographic S-folds must be coincident in this crystal fo rm