HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEROCONVERSION IN WOMEN WITH GENITAL ULCERS

Genital ulcers are implicated as a risk factor enhancing susceptibilit y to human immunodeficiency virus type 1 (HIV-1) infection. A prospect ive study to determine the incidence of and risk factors associated wi th acquisition of HIV-1 in women with genital ulcers was done. HIV-1-s eronegative women with genital ulcers attending a clinic for sexually transmitted diseases in Nairobi were followed to HIV-1 seroconversion over a 6-month period. Of 81 women, 10 seroconverted to HIV-1. The cru de 6-month incidence of HIV-1 infection was 12%. Risk factors associat ed with seroconversion included cervical ectopy (rate ratio [RR], 4.9; 95% confidence interval [CI], 1.5-15.6) and pelvic inflammatory disea se (RR, 6.3; 95% CI, 1.9-20.4). Thus, cervical ectopy and pelvic infla mmatory disease may increase susceptibility to HIV-1 in women with gen ital ulcers.