STAPHYLOCOCCUS-AUREUS INFECTIONS IN PATIE NTS ON HEMODIALYSIS AND NASAL CARRIAGE - USE OF MUPIROCIN

Nasal carriage of Staphylococcus aureus represents a risk for infectio ns in chronic hemodialysis patients. The advantage to use local chemop rophylaxis for eradication of carriage has been reported and discussed . This study carried out at the hemodialysis center of CH Valenciennes reports die prevalence and the incidence of S. aureus carriage. We pr opose a strategy for mupirocin prophylaxis based on risk factors relat ed to hemodialysis patients (vascular access site, previously document ed staphylococcal infection, significant carriage) and to the clinical and microbiological follow-up. Activity of antibiotics, including mup irocin, against S. aureus strains were assessed (mupirocin MIC90 = 0,1 25 mg/l). The aim of the phenotyping study of the strains was to deter mine more precisely the epidemiological factors of several patients.