RESISTANCE OF STREPTOCOCCUS-PNEUMONIAE TO ANTIBIOTICS - INFLUENCE OF UNDERLYING DISEASES (AGE, COPD, HIV, UPPER RESPIRATORY-TRACT NEOPLASM

From january 1988 to december 1992, 143 Streptococcus pneumoniae strai ns were isolated from 136 patients hospitalized in the pulmonary care unit of CHI Creteil. Antibiotics below were tested : penicillin (P), u pon 139 strains, erythromycin (E), chloramphenicol (C), tetracycline ( T) and cotrimoxazole (SxT) upon 140 strains; 3 strains did not growth in subculture. Mean age of the population is 57 years (range 19-95). A ge above 50 years don't influence succeptibility to one of the antibio tics tested or multiply resistance (> 3 antibiotics). On the other han d resistance against erythromycine is favoured when patients are older than 70. This cut off don't influence multiply resistance. In COPD pa tients (93/136), resistance against tetracycline is enhanced. Eight pa tients have a HIV seropositivity and 22 an upper respiratory tract neo plasm. These two diseases don't influence resistance against antibioti cs. Among underlying diseases studied (age, COPD, upper respiratory tr act neoplasm), only age and COPD appear to influence Streptococcus pne umoniae resistance to the antibiotics tested.