ACUMINATOPYRONE - REVISED STRUCTURE AND PRODUCTION BY FUSARIUM-CHLAMYDOSPORUM AND FUSARIUM-TRICINCTUM

Acuminaropyrone, a recently described metabolite of Fusarium acuminatu m, was shown to be produced by several strains of Fusarium chlamydospo rum and F. tricinctum isolated from various substrates in different co untries. The structure of acuminatopyrone has been revised on the basi s of NOEDIF and HETCOR nmr experiments, and shown to be ethoxy-7,8-dim ethyl-2H-pyrano[4,3-b]pyridin-2-one. This structure is biosyntheticall y consistent with that of chlamydosporol and related compounds that ar e produced by the same fungal species.