PYODERMATITIS-PYOSTOMATITIS VEGETANS - A SPECIFIC MARKER FOR INFLAMMATORY BOWEL-DISEASE

In pyodermatitis-pyostomatitis vegetans annular pustular cutaneous les ions may precede, accompany, or follow the usually extensive vegetatin g oral disease. Sometimes only cutaneous or only oral lesions occur an d previously have been described as separate entities. Clinical, histo pathologic, and immunopathologic evidence clearly indicates this is on e disease and suggests that it is distinct from pemphigus vegetans. Th e association between pyodermatitis-pyostomatitis vegetans and inflamm atory bowel disease, most commonly ulcerative colitis, has been amply confirmed. Pyodermatitis-pyostomatitis vegetans should be considered a marker for inflammatory bowel disease.