THE USE OF METHOTREXATE FOR TREATMENT OF PSORIASIS IN PATIENTS WITH HIV-INFECTION

Authors
MAURER TA ZACKHEIM HS TUFFANELLI L BERGER TG
Citation
Ta. Maurer et al., THE USE OF METHOTREXATE FOR TREATMENT OF PSORIASIS IN PATIENTS WITH HIV-INFECTION, Journal of the American Academy of Dermatology, 31(2), 1994, pp. 372-375
Citations number
20
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Journal of the American Academy of Dermatology → ACNP
ISSN journal
01909622
Volume
31
Issue
2
Year of publication
1994
Part
2
Supplement
S
Pages
372 - 375
Database
ISI
SICI code
0190-9622(1994)31:2<372:TUOMFT>2.0.ZU;2-L
Abstract
The use of methotrexate (MTX) has been contraindicated for treatment o f severe psoriasis in HIV infection on the basis of six previously rep orted cases in which MTX appeared to potentiate opportunistic infectio ns and accelerate HIV disease. We describe three HIV-infected patients who were given MTX for severe psoriatic arthritis. In two patients op portunistic infections did not develop. On the basis of survival data, it is not clear that use of MTX adversely affected the natural course of their HIV disease.