EFFECT OF 11-BETA-SUBSTITUENTS ON THE REGIOSELECTIVE CHLORINATION OF ESTROGENS WITH 2,3,4,5,6,6-HEXACHLORO-2,4-CYCLOHEXADIENONE

Authors
ALI H VANLIER JE
Citation
H. Ali et Je. Vanlier, EFFECT OF 11-BETA-SUBSTITUENTS ON THE REGIOSELECTIVE CHLORINATION OF ESTROGENS WITH 2,3,4,5,6,6-HEXACHLORO-2,4-CYCLOHEXADIENONE, Steroids, 59(8), 1994, pp. 498-502
Citations number
29
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
59
Issue
8
Year of publication
1994
Pages
498 - 502
Database
ISI
SICI code
0039-128X(1994)59:8<498:EO1OTR>2.0.ZU;2-S
Abstract
The reaction of 11 beta-substituted estrogens with 2,3,4,5,6,6-hexachl oro-2,4-cyclohexadienone affords exclusively ortho-substituted monochl orinated products including a major 4-chloro and a minor 2-chloro deri vative. In the absence of an 11 beta-substituent, regioselectivity is lost, resulting in a mixture of 10 beta- and ortho-chlorinated product s.