THE CARBOXYLIC-ACID GROUP AS AN EFFECTIVE DIRECTOR OF ORTHO-LITHIATION

Authors
MORTIER J MOYROUD J BENNETAU B CAIN PA
Citation
J. Mortier et al., THE CARBOXYLIC-ACID GROUP AS AN EFFECTIVE DIRECTOR OF ORTHO-LITHIATION, Journal of organic chemistry, 59(15), 1994, pp. 4042-4044
Citations number
47
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
15
Year of publication
1994
Pages
4042 - 4044
Database
ISI
SICI code
0022-3263(1994)59:15<4042:TCGAAE>2.0.ZU;2-4
Abstract
Treatment of PhCO(2)H in tetrahydrofuran with 2.2 equiv of a 1:1 llith ium/N,N,N',N'-tetramethyl-1,2-ethylenediamine complex at -90 degrees C gave o-LiC6H4CO2Li, which was treated with electrophiles to give o-RC (6)H(4)CO(2)H (R = Me, SMe, Cl, Br) in good yields.