TRILINEAGE RESPONSE TO RHG-CSF WITH SUBSEQUENT CLONAL HEMATOPOIESIS IN A PATIENT WITH SEVERE BONE-MARROW APLASIA

Citation
M. Yasuda et al., TRILINEAGE RESPONSE TO RHG-CSF WITH SUBSEQUENT CLONAL HEMATOPOIESIS IN A PATIENT WITH SEVERE BONE-MARROW APLASIA, Leukemia & lymphoma, 14(3-4), 1994, pp. 347-351
Citations number
NO
Categorie Soggetti
Hematology
Journal title
ISSN journal
10428194
Volume
14
Issue
3-4
Year of publication
1994
Pages
347 - 351
Database
ISI
SICI code
1042-8194(1994)14:3-4<347:TRTRWS>2.0.ZU;2-O
Abstract
We treated a patient with severe aplastic anemia with long-term admini stration of recombinant human granulocyte-colony stimulating factor (r hG-CSF). When a trilineage response of hematopoiesis was obtained afte r the first treatment, a chromosomal change [45XX, -7] was observed in 20 of the 20 metaphases examined. Later, we were able to show a monoc lonal X inactivation pattern in the phosphoglycerate kinase (PGK) gene in the peripheral blood polymorphonuclear leukocytes and mononuclear cells, indicating the presence of clonal hematopoiesis regardless of t he disappearance of the karyotype abnormality. We suggest that it is i mportant to pay close attention to the appearance of clonal hematopoie sis during the administration of G-CSF to patients with idiopathic sev ere bone marrow aplasia.