MDM2 GENE AMPLIFICATION IN PRIMARY BREAST -CANCER

Authors
FONTANA X FERRARI P ABBES M MONTICELLI J NAMER M BUSSIERE F
Citation
X. Fontana et al., MDM2 GENE AMPLIFICATION IN PRIMARY BREAST -CANCER, Bulletin du cancer, 81(7), 1994, pp. 587-592
Citations number
33
Categorie Soggetti
Oncology
Journal title
Bulletin du cancer → ACNP
ISSN journal
00074551
Volume
81
Issue
7
Year of publication
1994
Pages
587 - 592
Database
ISI
SICI code
0007-4551(1994)81:7<587:MGAIPB>2.0.ZU;2-Z
Abstract
mdm2 (mouse double minute) protein seems lead to p53 inactivation and therefore might potentially play a role in carcinogenesis. We have stu died mdm2 gene amplification from 239 primary breast cancer tissues. m dm2 gene was amplified in 10% of cases (25/239). mdm2 amplification wa s associated with c-erbB2 amplification (P < 10(-3)). No other correla tion was found. However there was inverse correlation between c-erbB2 gene amplification and hormonal receptors (P < 10(-4)), only from pati ents without mdm2 gene amplification.