PNEUMOCYSTIS-CARINII IS RESISTANT TO IMIDAZOLE ANTIFUNGAL AGENTS

Because Pneumocystis carinii is closely related to fungi, drugs useful for treating mycoses have been considered for use in the treatment of P. carinii pneumonia. Six antifungal imidazole drugs were tested for their activities against P. carinii in a short-term culture screen and in animals. None of the imidazoles tested was effective in inoculated infected rats, and only miconazole showed slight effects in culture a t the high concentration of 10 mu g/ml. Analysis of cell membranes fro m culture-grown P. carinii showed that ergosterol, the target for this class of antifungal agents, was absent, so that the lack of effect of these agents is rational.