FATAL THROMBOEMBOLISM IN ACUTE PROMYELOCYTIC LEUKEMIA DURING ALL-TRANS-RETINOIC ACID THERAPY COMBINED WITH ANTIFIBRINOLYTIC THERAPY FOR PROPHYLAXIS OF HEMORRHAGE

Authors
HASHIMOTO S KOIKE T TATEWAKI W SEKI Y SATO N AZEGAMI T TSUKADA N TAKAHASHI H KIMURA H UENO M ARAKAWA M SHIBATA A
Citation
S. Hashimoto et al., FATAL THROMBOEMBOLISM IN ACUTE PROMYELOCYTIC LEUKEMIA DURING ALL-TRANS-RETINOIC ACID THERAPY COMBINED WITH ANTIFIBRINOLYTIC THERAPY FOR PROPHYLAXIS OF HEMORRHAGE, Leukemia, 8(7), 1994, pp. 1113-1115
Citations number
16
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
8
Issue
7
Year of publication
1994
Pages
1113 - 1115
Database
ISI
SICI code
0887-6924(1994)8:7<1113:FTIAPL>2.0.ZU;2-#
Abstract
In contrast to patients with disseminated intravascular coagulation (D IC) due to other causes, patients with acute promyelocytic leukemia (A PL) receiving standard cytotoxic chemotherapy can be treated safely wi th antifibrinolytic drugs for prophylaxis of hemorrhage, without the o ccurrence of thromboembolic complications. However, such drugs should be used cautiously in APL patients who are receiving all-trans retinoi c acid (ATRA) differentiation therapy. We report here a patient with A PL who had fatal thromboembolism after receiving ATRA and tranexamic a cid therapy.