ARTEETHER ADMINISTRATION IN HUMANS - PRELIMINARY STUDIES OF PHARMACOKINETICS, SAFETY AND TOLERANCE

Authors
KAGER PA SCHULTZ MJ ZIJLSTRA EE VANDENBERG B VANBOXTEL CJ
Citation
Pa. Kager et al., ARTEETHER ADMINISTRATION IN HUMANS - PRELIMINARY STUDIES OF PHARMACOKINETICS, SAFETY AND TOLERANCE, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, 1994, pp. 53-54
Citations number
5
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
88
Year of publication
1994
Supplement
1
Pages
53 - 54
Database
ISI
SICI code
0035-9203(1994)88:<53:AAIH-P>2.0.ZU;2-R
Abstract
The recently developed artemisinin derivative arteether was administer ed by intramuscular injection to healthy male subjects in a single dos e (n=23) and a multiple dose study (n=27). The drug was well tolerated . Clinical, neurological, electrocardiographic and biochemical monitor ing did not reveal significant toxicity. Apart from some increase in e osinophil numbers, no haematological abnormality was seen. Preliminary pharmacokinetic data showed a long elimination half life of 25-72 h a nd marked accumulation in the multiple dose study.