SYNTHESIS OF ALPHA-MANNOSYLATED ERGOT ALKALOIDS EMPLOYING ALPHA-MANNOSIDASE

Authors
SCIGELOVA M KREN V NILSSON KGI
Citation
M. Scigelova et al., SYNTHESIS OF ALPHA-MANNOSYLATED ERGOT ALKALOIDS EMPLOYING ALPHA-MANNOSIDASE, Biotechnology letters, 16(7), 1994, pp. 683-688
Citations number
11
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
16
Issue
7
Year of publication
1994
Pages
683 - 688
Database
ISI
SICI code
0141-5492(1994)16:7<683:SOAEAE>2.0.ZU;2-1
Abstract
The ergot alkaloids elymoclavine, ergometrine and chanoclavine were al pha-mannosylated with alpha-mannosidase as catalyst. The kinetic react ion with p-nitrophenyl alpha-mannoside as glycosyl donor gave ca 28 % yield of chanoclavine alpha-mannoside, whereas the equilibrium reactio n with mannose as the glycosyl donor gave ca 11 % yield. However, in t he case of elymoclavine and ergometrine, higher yields of alpha-mannos ides were obtained with the equilibrium approach (18 and 13 %).