C. Lafforguedelorme et al., CONTINUOUS ALCOHOLIC FERMENTATION WITH SACCHAROMYCES-CEREVISIAE RECYCLE BY TANGENTIAL FILTRATION - KEY POINTS FOR PROCESS MODELING, Biotechnology letters, 16(7), 1994, pp. 741-746
A mathematical model, taking in count ethanol inhibition and limitatio
n effects with emphasis to phenomena linked to biomass is proposed. No
tions of critical cell concentrations, corresponding to the appearance
of inhibition or limitation effects and transfer limitations are intr
oduced. Available space for yeast growth is also considered. The agree
ment between simulation and experimental results demonstrates that thi
s model is sufficiently reliable for predictive performance of bioreac
tors with high cell concentrations.