S. Rex et Kd. Schulze, STABILITY ANALYSIS OF AN ELECTROCHEMICAL MODEL FOR EXCITABLE BIOMEMBRANES, Zeitschrift für physikalische Chemie, 186, 1994, pp. 65-76
Citations number
6
Categorie Soggetti
Chemistry Physical","Physics, Atomic, Molecular & Chemical
Stability investigations at a membrane model are presented. The model
includes a 4-state gating mechanism as instability-generating element.
The gating mechanism is characterized by appropriate rate constants f
or the ion channel rearrangement, and by changes of dipole charges. Th
e influence of these physico-chemical parameters on the model dynamics
was elucidated numerically. For the investigations a special strategy
was developed which uses the eigenvalues for the discrimination of th
e type of instability (oscillations or saddle point behaviour) occurri
ng at given model conditions. The model calculations showed that a cha
nge of the dipole charge by two units is sufficient for membrane oscil
lations. This change could be realized, e.g. by association/dissociati
on of a divalent ion at the end of an ion channel.