ACCELERATED TRANSACYLATION OF UNACTIVATED PHENYL-ESTERS AT PHYSIOLOGICAL PH WITH BETA-CYCLOALTRAMINE

Authors
GROANING MD DSOUZA VT
Citation
Md. Groaning et Vt. Dsouza, ACCELERATED TRANSACYLATION OF UNACTIVATED PHENYL-ESTERS AT PHYSIOLOGICAL PH WITH BETA-CYCLOALTRAMINE, Supramolecular chemistry, 8(1), 1996, pp. 5-8
Citations number
25
Categorie Soggetti
Chemistry
Journal title
Supramolecular chemistry → ACNP
ISSN journal
10610278
Volume
8
Issue
1
Year of publication
1996
Pages
5 - 8
Database
ISI
SICI code
1061-0278(1996)8:1<5:ATOUPA>2.0.ZU;2-G
Abstract
The recently reported novel cyclodextrin, beta-cycloaltramine, exhibit s a 5.3 x 10(4) fold acceleration (compared to buffer) in transacylati on of unactivated phenyl esters at physiological pH and follows satura tion kinetics similar to enzymes. This acceleration is attributed to t he change of the nucleophile and better binding of the substrate by th is novel flexible host.