PERMEATION OF RABBIT COMMON CAROTID ARTERIES WITH DIMETHYL-SULFOXIDE

Proton nuclear magnetic resonance has been used to measure the kinetic s of permeation of dimethyl sulfoxide in the common carotid artery of the rabbit. The process is described by the following exponential equa tions, where t = time in minutes: % Unexchanged at 2 degrees C = 70e(- 0.515t) + 30e(-0.104t) and % Unexchanged at 22 degrees C = 70e(-1.790t ) + 30e(-0.146t). The times required for 95% equilibration were 13 min at 22 degrees C and 18 min at 2 degrees C. The corresponding times fo r 99% equilibration were 24 and 32 min, respectively. (C) 1994 Academi c Press, Inc.